Changes of immune responses in newly diagnosed pulmonary tuberculosis patients during treatment
- Author:
Huong Thanh Phan
- Publication Type:Journal Article
- Keywords:
pulmonary tuberculosis
- MeSH:
Tuberculosis, Pulmonary;
Diagnosis;
Therapeutics
- From:Journal of Preventive Medicine
1998;8(3):43-49
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In order to find out the relation between immune response and clinical changes in tuberculosis patient, and characters of CMI at the onset of the disease as well as the end of treatment, the follow-up of changes in cell mediated immune response (HIR). The study was carried out at different times before treatment [T2], and at the end of the treatment [T9] in 42 newly diagnosed pulmonary tuberculosis patients. Our results showed that only changes in CMI were significant and the pattern of cellular immune response was relative to the severity of the illness. In early-diagnosed patients (1-2 months) when the lymphoproliferative response in vitro increased, there was a enhancing factor in the patient's cell culture supernatant; whereas in late-diagnosed patients (6-12 months), when the lymphoproliferative response in vitro increased, there was a inhibitory factor. The patterns of soluble factor production was relative to effect of treatment (the patients whose mononuclear cells produced inhibitory factors at T9 were cured patients and no relapse found, the patients whose mononuclear cells still produced enhancing factors at T9 were uncured patients and could suffer from a relapse 3-6 months later).
