Change of Renal Function and Morphology in 3/4 Nephrectomized Rats.
- Author:
Hak Ryong CHOI
1
Author Information
1. Department of Urology, Ewha Womans University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
renal growth;
nephrectomy
- MeSH:
Animals;
Humans;
Hypertrophy;
Male;
Nephrectomy;
Rats*;
Sclerosis
- From:Korean Journal of Urology
1996;37(4):385-391
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To examine the effect renal mass reduction on compensatory renal hypertrophy and progressive glomerular sclerosis, 3/4 nephrectomy was performed in mature male rats. Serial changes in renal histology and function were investigated at weeks 1, 2, 6 and 12 after 3/4 nephrectomy. Mean glomerular diameter increased 29% during the first week thereafter the growth rate of glomeruli was similar to that of sham operated control's. Peak renal function was achieved at 6 weeks and thereafter progressively decreased. The prominent glomerular sclerosis was found at 12th week. These results suggest that renal growth after renal mass reduction is a pathologic process ensuing progressive renal damage.
