A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review.
10.3345/kjp.2016.59.11.S60
- Author:
Na Yeon KIM
1
;
Joon Hwan KIM
;
Jin Suk PARK
;
Soo Hyun KIM
;
Yeon Kyung CHO
;
Dong Hyun CHA
;
Ki Eun KIM
;
Myung Suh KANG
;
Kyung Ah LIM
;
Youn Ho SHEEN
Author Information
1. Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
- Publication Type:Case Report
- Keywords:
Anemia;
Hemolysis;
Kawasaki disease;
Reticulocytes
- MeSH:
Anemia;
Anemia, Hemolytic*;
Anemia, Hypochromic;
Aspirin;
Coombs Test;
Edema;
Erythrocytes;
Exanthema;
Fever;
Fragaria;
Hand;
Hematocrit;
Hemolysis;
Humans;
Immunization, Passive*;
Immunoglobulins*;
Infant*;
Male*;
Mucocutaneous Lymph Node Syndrome*;
Neutrophils;
Reticulocyte Count;
Reticulocytes;
Tongue
- From:Korean Journal of Pediatrics
2016;59(Suppl 1):S60-S63
- CountryRepublic of Korea
- Language:English
-
Abstract:
Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.
