Seizure Induction by Artemisia Annua in an Epilepsy Patient Taking Levetiracetam.
- Author:
Wonsik NAM
1
;
Oh Young KWON
;
Do Hyung KIM
;
Minjung KIM
;
Hye Hoon KANG
;
Da Hye JEONG
;
Heejeong JEONG
;
Seungnam SON
;
Soo Kyoung KIM
;
Heeyoung KANG
;
Ki Jong PARK
;
Nack Cheon CHOI
;
Byeonghoon LIM
Author Information
1. Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea. mnkwon21@hanmail.net
- Publication Type:Case Report
- Keywords:
Artemisia annua;
Seizure;
Anticonvulnts
- MeSH:
Anticonvulsants;
Artemisia;
Artemisia annua*;
Cytochrome P-450 Enzyme System;
Epilepsy*;
Humans;
Metabolism;
Seizures*
- From:Journal of the Korean Neurological Association
2015;33(1):44-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Artemisia annua is a wormwood. Because it may induce Cytochrome P450 2C19 enzyme, Artemisia annua may have an influence on antiepileptic drugs which are substrates for the enzyme. This influence may negatively affect seizure control of epilepsy patient. We present a patient whose seizures were induced by Artemisia annua, despite he was taking levetiracetam which is not a substrate for the hepatic enzyme. Therefore there would be another mechanism of seizure induction of Artemisia annua besides hepatic metabolism.
