A Case of Tertian Malaria which Recurred Three Times Despite Standard Chloroquine-primaquine Therapy.
- Author:
Hae Young LEE
1
;
Ju Yong HAN
;
Ki Deok LEE
;
Wan Burm PARK
;
Sung Han KIM
;
Cheol In KANG
;
Jung Joo MOON
;
Myung Don OH
;
Kang Won CHOE
Author Information
1. Younchon Health and Medical Center.
- Publication Type:Case Report
- Keywords:
Plasmodium vivax;
Chloroquine;
Primaquine;
Relapse
- MeSH:
Adult;
Chemoprevention;
Chloroquine;
Fever;
Follow-Up Studies;
Gyeonggi-do;
Humans;
Hydroxychloroquine;
Malaria*;
Malaria, Vivax;
Male;
Military Personnel;
Plasmodium vivax;
Primaquine;
Recurrence;
Schizonts;
Trophozoites
- From:Korean Journal of Infectious Diseases
2002;34(6):396-400
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Plasmodium vivax malaria, which used to be endemic in the past, re-emerged in 1993 and the number of cases has increased annually. Though there has been no proven endemic drug-resistant malaria case reported, widespread use of anti-malarial chemoprophylaxis for the military personnel could cause emergence of resistance. We herein report a case of tertian malaria, which recurred three times despite the standard chloroquine-primaquine therapy. The patient is 40-year-old male, lives in Dongducheon city, Gyeonggy province, and has never been abroad. He visited hospital in September 2000, because of fever. His blood smear revealed ring forms and trophozoites of P. vivax. He took hydroxychloroquine for 3 days and primaquine for 14 days. His symptoms disappeared then. After 7 months he got fever for 2 days and his blood smear revealed schizonts of P. vivax. He took the same medicines and got well next day. Fever recurred 4 month later, and trophozoites were observed on the blood smear. Hydroxychloroquine and primaquine were prescribed in the same way and fever disappeared. Forty three days later, he had fever and positive blood smear of P. vivax trophozoite. Fever disappeared on the day drug was administered and no malaria was detected in follow up smear of 7 and 14 days. He was free of fever in follow up at 3 months later.
