Effect of Clozapine on Plasma Prolactin Levels in Schizophrenic Patients.
- Author:
Chul Eung KIM
1
;
Min Hee KANG
Author Information
1. Department of Psychiatry, School of Medicine, Inha University, Inchon, Korea. kce320@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Prolactin;
Clozapine
- MeSH:
Antipsychotic Agents;
Clozapine*;
Humans;
Hyperprolactinemia;
Plasma*;
Prolactin*;
Radioimmunoassay;
Risperidone;
Schizophrenia
- From:Korean Journal of Psychopharmacology
1999;10(1):65-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate the effect of clozapine on seam prolactin concentration in schizophrenic patients. METHOD: The subjects composed of 3-schizophrenic patients with hyperprolactinemia after treatment with risperidone and 9-tratment resistant chronic schizophrenic patients. Serum prolactin concentration was measured by radioimmunoassay method before clozapine administration and artier 1 and 4 week of treatment. Data were analysed by the SAS program. Statistical methods employed was Wilcoxon-sign rank test. RESULTS: 1) Clozapine had improving effect on 3 risperidone-induced hyperprolactinemic patients. 2) Clozapine did not have significant effect on serum prolactin levels in 9-tratment resistant chronic schizophrenic patients. CONCLUSION: Clozapine has minimal effects on serum prolactin levels in schizophrenic patients as well as improving effect on antipsychotics-induced hyperprolactinemia. We recommend atypical antipsychotics such as clozapine as alternative treatments for complicated hyperprolactinemia induced by other antipsychotics.
