Significance of the Expression of p27(Kip1) Protein in Human Breast Cancer.
10.4048/jkbcs.2002.5.4.291
- Author:
Chan Yong KIM
1
;
Keun Ho YANG
;
Byung Noe BAE
;
Ki Hwan KIM
;
Hong Joo KIM
;
Young Duck KIM
;
Hong Yong KIM
;
KyeongMee PARK
;
Sehwan HAN
Author Information
1. Department of Surgery, Inje University, Sanggye Paik Hospital, Seoul, Korea. shwhan@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Breast cancer;
p27(Kip1);
Tissue microarrays;
Prognosis
- MeSH:
Breast Neoplasms*;
Breast*;
Cell Cycle;
Drug Therapy;
Estrogens;
Humans*;
Mitotic Index;
Phenotype;
Phosphotransferases;
Prognosis
- From:Journal of Korean Breast Cancer Society
2002;5(4):291-297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: p27(Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. It binds to a variety of cyclin/CDK complexes, inhibits kinase activity and blocks the cell cycle as a negative regulator. Reduced p27(Kip1) expression has been reported to be a significant predictor of poor survival in numerous human breast cancers. We executed p27(Kip1) protein assay in primary breast cancer and compared these result with known prognostic parameters. METHODS: Immunohistochemical assay was performed on tissue microarrays from 183 patients with breast cancer to evaluate the biologic and clinical significance of p27(Kip1) expression. RESULTS: Decreased p27(Kip1) expression was significantly associated with clinical stage (P=0.027), low nuclear grade (P<0.001), high histologic grade (P<0.001), high score mitotic index (P<0.001), increased Ki67 labeled index (P=0.006) and negative estrogen receptor status (P=0.0024). In survival analysis, p27(Kip1) was useful to predict disease- free survival (P=0.0106) and overall survival (P=0.0154) of the patient after surgery followed by chemotherapy or radiation therapy. CONCLUSION: Reduced expression of p27(Kip1) protein was as sociated with biologically aggressive phenotype of breast cancer and was an useful to predict patient outcome.
