Osseointegration of the titanium implant coated with rhTGF-beta2/PLGA particles by electrospray: a preliminary microCT analyzing rabbit study.
10.4047/jkap.2014.52.4.298
- Author:
Woo Sung LEE
1
;
Seong Kyun KIM
;
Seong Joo HEO
;
Jai Young KOAK
;
Joo Hee LEE
;
Ji Man PARK
;
Yoon Kyung PARK
Author Information
1. Department of Prosthodontics, Seoul National University Dental Hospital, School of Dentistry, Seoul National University, Seoul, Republic of Korea. ksy0617@snu.ac.kr
- Publication Type:Original Article
- Keywords:
TGF-beta2;
PLGA;
Titanium;
Implant;
Osseointegration
- MeSH:
Humans;
Osseointegration*;
Rabbits;
Tibia;
Titanium*;
Transforming Growth Factor beta2;
X-Ray Microtomography*
- From:The Journal of Korean Academy of Prosthodontics
2014;52(4):298-304
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This preliminary rabbit study was conducted to evaluate the effect of recombinant human transforming growth factor-beta2 (rhTGF-beta2)/poly lactic-co-glycolic acid (PLGA) coating on osseointegration of the titanium (Ti) implant. MATERIALS AND METHODS: Eight Ti implants were anodized with 300 voltages for three minutes. Four of those were coated with rhTGF-beta2/PLGA by an electrospray method as the experimental group. The implants were placed into tibiae of four New Zealand rabbits, two implants per a tibia, one implant per each group. After 3 and 6 weeks, every two rabbits were sacrificed and micro-computed tomography (microCT) was taken for histomorphometric analysis. RESULTS: In scanning electron microscope (SEM) image, the surface of rhTGF-beta2/PLGA coated Ti implant showed well distributed particles. Although statistically insignificant, microCT analysis showed that experimental group has higher bone volume / total volume (BV/TV) and trabecular thickness (Tb.Th) values relatively. Cross sectional view also showed more newly formed bone in the experimental group. CONCLUSION: In the limitation of this study, rhTGF-beta2/PLGA particles coating on the Ti implant show the possibility of more favorable quantity of newly formed bone after implant installation.
