Synchronous Adenocarcinoma and Mantle Cell Lymphoma of the Stomach.
10.3349/ymj.2007.48.6.1061
- Author:
Yong Il KIM
1
;
Min Young KOO
Author Information
1. Department of Surgery, Ewha Womans University College of Medicine, Seoul, Korea. kimyi@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Synchronous;
adenocarcinoma;
mantle cell lymphoma
- MeSH:
Adenocarcinoma/complications/metabolism/*pathology;
Antigens, CD20/analysis;
Antigens, CD5/analysis;
Cyclin D1/analysis;
Humans;
Immunohistochemistry;
Lymphoma, Mantle-Cell/complications/metabolism/*pathology;
Male;
Middle Aged;
Stomach/chemistry/*pathology;
Stomach Neoplasms/complications/metabolism/*pathology
- From:Yonsei Medical Journal
2007;48(6):1061-1065
- CountryRepublic of Korea
- Language:English
-
Abstract:
Synchronous occurrence of mantle cell lymphoma (MCL) and gastric cancer in the same patient has not yet been reported in the English literature. MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most series. A 62-year-old man was referred to our hospital for evaluation of an abnormal gastric lesion. The endoscopic finding was compatible with type IIc early gastric cancer (EGC) in the middle third of the stomach, and a biopsy of the lesion proved to be carcinoma. Radical total gastrectomy with splenectomy and Roux-en-Y esophagojejunostomy were performed. The resected specimen revealed two grossly separated lesions. Postoperative histological examination reported both adenocarcinoma and MCL. Immunohistochemical staining showed positivity for CD5, CD20, and cyclin D1 in the infiltrated lymphoid cells. MCL is an aggressive non-Hodgkin's lymphoma, and the current treatment approach is still unsatisfactory. Further advancements in the understanding of the synchronous occurrence of both diseases, and more efforts on investigations of treatment are needed.
