Extrapulmonary Small Cell Carcinoma of the Liver: Clinicopathological and Immunohistochemical Findings.
10.3349/ymj.2007.48.6.1066
- Author:
Suk Jin CHOI
1
;
Joon Mee KIM
;
Jee Young HAN
;
Seung Ik AHN
;
Jin Soo KIM
;
Lucia KIM
;
In Suh PARK
;
Young Chae CHU
Author Information
1. Department of Pathology, Inha University College of Medicine, Incheon, Korea. jmkpath@inha.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Small cell carcinoma;
neuroendocrine carcinoma;
immunohistochemistry;
liver
- MeSH:
Aged, 80 and over;
Antigens, CD56/analysis;
Carcinoma, Small Cell/metabolism/*pathology;
Chromogranins/analysis;
Female;
Humans;
Immunohistochemistry;
Liver/chemistry/*pathology;
Liver Neoplasms/metabolism/*pathology;
Lung Neoplasms/pathology;
Phosphopyruvate Hydratase/analysis;
Synaptophysin/analysis
- From:Yonsei Medical Journal
2007;48(6):1066-1071
- CountryRepublic of Korea
- Language:English
-
Abstract:
Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
