Posttransplant Lymphoproliferative Disease(PTLD) following Renal Transplantation.
- Author:
Song Cheol KIM
1
;
Hyuk Jai JANG
;
Eun Sil YOO
;
Duck Jong HAN
Author Information
1. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Korea.
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disease;
Renal transplantation
- MeSH:
Acyclovir;
Adult;
Herpesvirus 4, Human;
Humans;
Hyperplasia;
Immunoglobulins;
Immunosuppression;
In Situ Hybridization;
Kidney Transplantation*;
Lymphoma;
Lymphoma, Large-Cell, Immunoblastic;
Lymphoproliferative Disorders;
Prognosis;
Radiotherapy
- From:The Journal of the Korean Society for Transplantation
1997;11(2):337-
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disease(PTLD) represents a diverse lymphoproliferative disorder ranging from non-specific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus infection and high dose immunosuppression. EBV detection and immunotyping including immunoglobulin clonality is crucial for prediction of prognosis and treatment modality. We report one case of PTLD developed 5 months after renal transplantation in 33 year-old man. Clinical manifestion was submandibular mass, and EBV was detected by in situ hybridization. Histology and immunotyping revealed immunoblastic lymphoma andl lambda chain monoclonality. He has been treated with reduction of immunosuppression, acyclovir and radiotherapy, and is in stable condition with normal renal function at postoperative 11months without evidence of disease reccurrence.
