Effects of retinoic acid on ischemic brain injury-induced eurogenesis.
- Author:
Dae Soo JUNG
1
;
Sun Yong BAEK
;
Kyu Hyun PARK
;
Young In CHUNG
;
Hak Jin KIM
;
Chi Dae KIM
;
Min Kyoung CHO
;
Myoung Eun HAN
;
Kyung Pil PARK
;
Bong Seon KIM
;
Jae Bong KIM
;
Sae Ock OH
Author Information
1. Department of Neurology, School of Medicine, Pusan National University, Busan 602-739, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
angiogenesis;
cerebral infarction;
gliosis;
tretinoin
- MeSH:
Animals;
Brain/blood supply;
Cell Differentiation;
Cell Proliferation;
Ischemic Attack, Transient/metabolism/*pathology;
Male;
Neovascularization, Pathologic;
Neuroglia/pathology/physiology;
Neurons/pathology/*physiology;
Rats;
Rats, Sprague-Dawley;
Tretinoin/*pharmacology/physiology
- From:Experimental & Molecular Medicine
2007;39(3):304-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
