The clinical characteristics of noncardiac chest pain and treatment response in non-erosive reflux disease (NERD).
- Author:
Tae Hyuck CHOI
1
;
Dong Ho LEE
;
Yu Jeong JEONG
;
Byoung Hwan LEE
;
Tae Jun HWANG
;
Young Soo PARK
;
Na Young KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Bundang Hospital, Seongnam, Korea. dhljohn@snubh.org
- Publication Type:Original Article
- Keywords:
Noncardiac chest pain;
Non-erosive reflux disease;
Proton pump inhibitors
- MeSH:
Chest Pain;
Coronary Artery Disease;
Depression;
Esophageal Motility Disorders;
Female;
Gastroesophageal Reflux;
Heart Valve Diseases;
Heartburn;
Humans;
Hydrogen-Ion Concentration;
Incidence;
Male;
Manometry;
Proton Pump Inhibitors;
Proton Pumps;
Thorax;
Tuberculosis
- From:Korean Journal of Medicine
2010;79(1):16-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Noncardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of noncardiac origin. Gastroesophageal reflux disease (GERD) is by far the most common cause of NCCP. We evaluated the incidence of some esophageal abnormalities as a cause of NCCP and the treatment response to a proton pump inhibitor (PPI). METHODS: Forty seven NCCP cases were selected from 184 cases who underwent 24-hour ambulatory pH monitoring or esophageal manometry. Patients were excluded if they had a history of gastrointestinal surgery, pancreatobiliary disorder, coronary artery disease, valvular heart disease, depression or tuberculosis. In this study, all GERD patients had non-erosive reflux disease (NERD). RESULTS: Of the 47 NCCP cases, 30 (63.8%) were female and 17 (36.2%) were male. Only 7 (14.9%) cases had typical GERD symptoms such as acid regurgitation and heartburn. Of the 47 NCCP cases, 12 (25.5%) had GERD-related NCCP, and six (12.8%) had esophageal motility disorder. Of the 12 cases diagnosed as GERD-related NCCP, nine (75.0%) showed a satisfactory PPI response. The PPI was effective for GERD-related NCCP compared with non-GERD related NCCP (p=0.015). CONCLUSIONS: About 40% of NERD patients with NCCP had an esophageal disorder including GERD and esophageal motility disorder. A PPI was effective for GERD-related NCCP.
