Impact of Statin Treatment on Strut Coverage after Drug-Eluting Stent Implantation.
- Author:
Yongsung SUH
1
;
Byeong Keuk KIM
;
Dong Ho SHIN
;
Jung Sun KIM
;
Young Guk KO
;
Donghoon CHOI
;
Yangsoo JANG
;
Myeong Ki HONG
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords: Stent; optical coherence tomography; statin
- MeSH: Adult; Coronary Angiography; *Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use; Lipoproteins, LDL/blood; Male; Middle Aged; Pravastatin/therapeutic use; *Prosthesis Implantation; Quinolines/therapeutic use; Tomography, Optical Coherence; Treatment Outcome
- From:Yonsei Medical Journal 2015;56(1):45-52
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To evaluate the effect of statin treatment on strut coverage after drug-eluting stent (DES) implantation. MATERIALS AND METHODS: In this study, 60 patients were randomly assigned to undergo sirolimus-eluting stent (SES) or biolimus-eluting stent (BES) implantation, after which patients were randomly treated with pitavastatin 2 mg or pravastatin 20 mg for 6 months. The degree of strut coverage was assessed by 6-month follow-up optical coherence tomography, which was performed in 52 DES-implanted patients. RESULTS: The percentages of uncovered struts were 19.4+/-14.7% in pitavastatin-treated patients (n=25) and 19.1+/-15.2% in pravastatin-treated patients (n=27; p=0.927). A lower percentage of uncovered struts was significantly correlated with a lower follow-up low-density lipoprotein (LDL) cholesterol level (r=0.486; p=0.009) and a greater decline of the LDL cholesterol level (r=-0.456; p=0.015) in SES-implanted patients, but not in BES-implanted patients. In SES-implanted patients, the percentage of uncovered struts was significantly lower among those with LDL cholesterol levels of less than 70 mg/dL after 6 months of follow-up (p=0.025), but no significant difference in this variable according to the follow-up LDL cholesterol level was noted among BES-implanted patients (p=0.971). CONCLUSION: Lower follow-up LDL cholesterol levels, especially those less than 70 mg/dL, might have a protective effect against delayed strut coverage after DES implantation. This vascular healing effect of lower LDL cholesterol levels could differ according to the DES type.
