Molecular Classification of Triple-Negative Breast Cancer.
10.4048/jbc.2016.19.3.223
- Author:
Sung Gwe AHN
1
;
Seung Jun KIM
;
Cheungyeul KIM
;
Joon JEONG
Author Information
1. Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. gsjjoon@yuhs.ac
- Publication Type:Review
- Keywords:
Breast neoplasms;
Gene expression;
Triple negative breast neoplasms
- MeSH:
Breast Neoplasms;
Classification*;
Gene Expression;
Phenobarbital;
Population Characteristics;
Receptors, Androgen;
Triple Negative Breast Neoplasms*
- From:Journal of Breast Cancer
2016;19(3):223-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these studies identically suggested that TNBC consists of four major subtypes: basal-like, mesenchymal, luminal androgen receptor, and immune-enriched. By reviewing these methods of classifications of TNBC, we highlight the unmet need to develop a molecular classifier suited for TNBC.
