A Case Report of Treatment of Renal Insufficiency and Toxic Hepatitis Caused By Amlodipine Intoxication.
- Author:
Jun Hong PARK
1
;
Seong Jung KIM
;
Nam Soo CHO
Author Information
1. Department of Emergency Medicine, Chosun University Hospital, Gwangju, Korea. ksj@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Amlodipine;
Renal Insufficiency;
Hepatitis;
Toxic
- MeSH:
Acidosis;
Amlodipine*;
Arrhythmias, Cardiac;
Bradycardia;
Calcium;
Calcium Channels;
Critical Illness;
Drug-Induced Liver Injury*;
Glucagon;
Hepatitis;
Humans;
Hyperglycemia;
Hypertension;
Hypotension;
Infarction;
Insulin;
Phosphodiesterase Inhibitors;
Renal Insufficiency*;
Respiration;
Seizures;
Shock, Cardiogenic
- From:Journal of the Korean Society of Emergency Medicine
2006;17(3):273-276
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amlodipine is widely used in the management of diverse cardiovascular conditions, including hypertension, arrhythmias, angina and myocardiac infarction. When overdosed, the drugs cause hypotension, bradycardia, cardiogenic shock, mental change, generalized seizure, hyperglycemia with metabolic acidosis, rarely toxic hepatitis and renal insufficiency. Initial management of critically ill patients consists of supporting airway, breathing and circulation. Maintenance of adequate circulation in poisoned patients often requires a multitude of simultaneous therapies including intravenous fluids, vasopressors, calcium, glucagon, phosphodiesterase inhibitors and high-dose insulin. We report a case of successful treatment of renal insufficiency and toxic hepatitis caused by calcium channel blocker intoxication.
