Changing Molecular Epidemiology of Group B Streptococcus in Korea.
10.3346/jkms.2010.25.6.817
- Author:
Yong Soo SEO
1
;
Usha SRINIVASAN
;
Kwan Young OH
;
Jung Hwan SHIN
;
Jeong Don CHAE
;
Moon Young KIM
;
Jae Hyug YANG
;
Hye Ryung YOON
;
Brady MILLER
;
Joan DEBUSSCHER
;
Betsy FOXMAN
;
Moran KI
Author Information
1. Department of Obstetrics and Gynecology, Eulji Hospital, Seoul, Korea.
- Publication Type:Original Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
- Keywords:
Drug Resistance, Microbial;
Genotype;
Pregnant Women;
Streptococcus Agalactiae;
Serotyping
- From:Journal of Korean Medical Science
2010;25(6):817-823
- CountryRepublic of Korea
- Language:English
-
Abstract:
The prevalence of group B streptococcus (GBS) among pregnant women and disease burdens in neonates and adults are increasing in Korea. Colonizing isolates, collected by screening pregnant women (n=196), and clinical isolates collected from clinical patients throughout Korea (n=234), were serotyped and screened for antibiotic resistance. Serotype III (29.8%) and V (27.7%) predominated, followed by Ia (17.0%). Antibiotic resistance was higher among clinical than colonizing isolates for erythromycin (35.1% and 26.9%; P=0.10) and for clindamycin (49.4% and 42.1%; P=0.17). erm(B) occurred in 91.9% of erythromycin resistant isolates, and 84.0% of isolates resistant to clindamycin. Only five isolates (4.2%) resistant to erythromycin were susceptible to clindamycin; by contrast, and unique to Korea, 34% of isolates resistant to clindamycin were erythromycin susceptible. Among these 60 erythromycin-susceptible & clindamycin-resistant isolates, 88% was serotype III, and lnu(B) was found in 89% of strains. Four fifths of the serotype V isolates were resistant to both erythromycin and clindamycin. Further characterization of the genetic assembly of these resistance conferring genes, erm(B) and lnu(B), will be useful to establish the clonal lineages of multiple resistance genes carrying strains.
