Effect of Inhaled Tiotropium on Spirometric Parameters in Patients with Tuberculous Destroyed Lung.
10.4046/trd.2014.77.4.167
- Author:
Ho Kee YUM
1
;
I Nae PARK
Author Information
1. Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. pulho@korea.com
- Publication Type:Original Article
- Keywords:
Pulmonary Function Tests;
Tiotropium;
Tuberculosis
- MeSH:
Forced Expiratory Volume;
Humans;
Korea;
Lung*;
Male;
Respiratory Function Tests;
Tuberculosis;
Vital Capacity;
Tiotropium Bromide
- From:Tuberculosis and Respiratory Diseases
2014;77(4):167-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In Korea, patients with destroyed lung due to tuberculosis (TB) account for a significant portion of those affected by chronic pulmonary function impairment. The objective of our research was to evaluate the efficacy of inhaled tiotropium bromide in TB destroyed lung. METHODS: We compared the effectiveness of inhaled tiotropium bromide for 2 months between pre- and post-treatment pulmonary function tests performed on 29 patients with destroyed lung due to TB. RESULTS: The mean age of the total number of patients was 63+/-9 years, where 15 patients were male. The pre-treatment mean forced expiratory volume in 1 second (FEV1) was 1.02+/-0.31 L (44.1+/-16.0% predicted). The pre-treatment mean forced vital capacity (FVC) was 1.70+/-0.54 L (52.2+/-15.8% predicted). Overall, the change in FEV1% predicted over baseline with tiotropium was 19.5+/-19.1% (p<0.001). Twenty patients (72%) got better than a 10% increase in FEV1 over baseline with tiotropium, but one patient showed more than a 10% decrease in FEV1. Overall, the change in FVC% predicted over baseline with tiotropium was 18.5+/-19.9% (p<0.001). Seventeen patients (59%) experienced greater than a 10% increase in FVC over baseline with tiotropium; 12 (41%) patients had stable lung function. CONCLUSION: The inhaled tiotropium bromide therapy may lead to improve lung functions in patients with TB destroyed lung. However, the long-term effectiveness of this treatment still needs to be further assessed.
