The Effects of Urapidil on Changes of Arterial Blood Pressure and Heart Rate to Endotracheal Intubation.
10.4097/kjae.1996.31.4.442
- Author:
Jun Goo LIM
1
;
Hee Sung YANG
;
Young Choo KIM
;
Suk Bong DUN
;
Chang Kyu SHIN
Author Information
1. Department of Anesthesiology, Pusan Medical Center, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Blood pressure;
Heart heart rate;
Intubation;
tracheal;
Sympath-etic nervous system pharmacology;
urapidil
- MeSH:
Anesthesia, General;
Arterial Pressure*;
Blood Pressure;
Dizziness;
Enflurane;
Headache;
Heart Rate*;
Heart*;
Hemodynamics;
Humans;
Intubation;
Intubation, Intratracheal*;
Nitrous Oxide;
Oxygen;
Thiopental;
Thorax;
Vascular Resistance;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
1996;31(4):442-447
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Urapidil is a new antihypertensive agent known to diminish total peripheral vascular resistance by postsynaptic alpha 1-adrenergic blockade and central sympatholytic activity. The purpose of this study was to determine its effectiveness and safety in preventing hemodynamic responses to endotracheal intubation under general anesthesia. METHODS: Thirty normotensive, ASA physical status I patients for elective surgery were selected randomly. They were divided into three groups(Group 1: control group with saline, Group 2: urapidil 0.4 mg/kg, Group 3: urapidil 0.5 mg/kg, n=10 in each group). The drugs were injected 3 minutes before induction with thiopental sodium(4 mg/kg) and succinylcholine(1 mg/kg). Endotracheal intubation was performed 5 minutes after the drugs injection. After endotracheal intubation, vecuronium 0.1 mg/kg was injected and 50% nitrous oxide in oxygen and 2Vol% enflurane were inhaled. We measured the blood pressure and the heart rate with noninvasive method at one minute interval for 5 minutes. RESULTS: In group 3, no significant increase in systolic blood pressure after endotracheal intubation was noted(p<0.05). Urapidil groups showed increase in heart rate at 1, 2 minutes after urapidil injection(p<0.05) and did not blunt increase in heart rate after endotracheal intubation. The side effects of urapidil(hypotension, dizziness, headache and chest tightness) occured in a patient of group 3. CONCLUSIONS: We found that the blood pressure response was effectively controlled, but the change in heart rate was not controlled by urapidil 0.5 mg/kg injection before induction.
