Comparison of coagulation factors and blood loss between O and non-O blood types following hydroxyethyl starch infusion.
10.4097/kjae.2010.58.4.344
- Author:
Soo Joo CHOI
1
;
Hyun Joo AHN
;
Jae Ik LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hyunjooahn@skku.edu
- Publication Type:Original Article
- Keywords:
Blood loss;
Blood type;
Coagulation;
Factor VIII;
Hydroxyethyl starch;
Thromboelastography
- MeSH:
Blood Coagulation Factors;
Blood Volume;
Factor VIII;
Hemorrhage;
Hetastarch;
Humans;
Reference Values;
Spine;
Thrombelastography;
von Willebrand Factor
- From:Korean Journal of Anesthesiology
2010;58(4):344-350
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood loss than non-O patients after infusion of 6% HES. METHODS: Thirty-four non-O and 20 type O patients scheduled for posterior lumbar interbody fusion (PLIF) involving 3 vertebrae or less from June 2007 to August 2008 were enrolled. Fifteen ml/kg of 6% HES was administered during the operation. Coagulation profiles was checked at pre-infusion (T0), 5 min after the end of infusion (T1), 3 hr after the end of infusion (T2), and 24 hr after the end of infusion (T3). Bleeding was measured during and after surgery for 24 hours. RESULTS: Baseline factor VIII concentration was lower and aPTT was longer in type O patients compared to those of non-O patients. 6% HES infusion decreased most of the coagulation factors at T1 in both groups, which were recovered in a time dependent manner. Factor VIII and aPTT of blood type O patients fell off the normal range at T1. However, other coagulation factors, thromboelastography variables, and blood loss were not different between the groups. CONCLUSIONS: Despite inborn low factor VIII which further decreased shortly after HES infusion, blood type O patients did not show more blood loss than non-O blood type after 15 ml/kg of HES infusion in PLIF surgery.
