Effectiveness of 99mTc-tetrofosmin for assessment of heart functions in micropigs.
- Author:
Min Young LEE
1
;
Sang Hun LEE
;
Jae Hong PARK
;
Jung Sun HEO
;
Yu Jin LEE
;
Han Na SUH
;
Jung Jun MIN
;
Young Soon SEO
;
Ho Jae HAN
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: ejection fraction (EF); heart function; micropig; 99mTc-tetrofosmin
- MeSH: Animals; Heart/*radionuclide imaging; Heart Function Tests/methods/*veterinary; Male; Organophosphorus Compounds/*diagnostic use; Organotechnetium Compounds/*diagnostic use; Swine; Swine, Miniature/*physiology; Tomography, Emission-Computed, Single-Photon/methods/*veterinary
- From:Journal of Veterinary Science 2007;8(3):223-227
- CountryRepublic of Korea
- Language:English
- Abstract: This study examined the suitability of a nuclear imagingtechnique using 99mTc-tetrofosmin as an agent to assess theheart functions of healthy micropigs. The mean age of thepigs was 360 days (male), and the mean body weight was35.3kg ranging from 34.5-36kg. There were no significantperfusion defects in any of the reconstructed images.Gated single-photon emission computed tomographyimaging can be used to calculate the ventricular volumeand ejection fraction (EF). In this case, an EF of 79% wascalculated from the ventricular volume of the end-systolicimage (10 ml) subtracted from that of the end-diastolicvolume (49 ml). A perfusion defect (particularly the apex,lateral wall) is unlikely because of the presence of apreserved wall motion in a segment with a defect. It isconcluded that quantitative cardiac scintigraphy, using99mTc-tetrofosmin is an adequate technique for estimatingthe heart functions of healthy micropigs.
