Identification of single-nucleotide polymorphisms of the prion protein gene in sika deer (Cervus nippon laiouanus).
- Author:
Hyun Jeong JEONG
1
;
Joong Bok LEE
;
Seung Yong PARK
;
Chang Seon SONG
;
Bo Sook KIM
;
Jung Rae RHO
;
Mi Hyun YOO
;
yung Hoon JEONG
;
Yong Sun KIM
;
In Soo CHOI
Author Information
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords: PRNP; sika deer; single-nucleotide polymorphism
- MeSH: Animals; Base Sequence; DNA/chemistry/genetics; Deer/*genetics; Genetic Variation; Molecular Sequence Data; Polymerase Chain Reaction/veterinary; Polymorphism, Single Nucleotide; Prions/*genetics; Sequence Analysis, DNA
- From:Journal of Veterinary Science 2007;8(3):299-301
- CountryRepublic of Korea
- Language:English
- Abstract: Polymorphisms of the prion protein gene (PRNP) havebeen detected in several cervid species. In order toconfirm the genetic variations, this study examined theDNA sequences of the PRNP obtained from 33 captivesika deer (Cervus nippon laiouanus) in Korea. A total ofthree single-nucleotide polymorphisms (SNPs) at codons100, 136 and 226 in the PRNP of the sika deer wereidentified. The polymorphic site located at codon 100 hasnot been reported. The SNPs detected at codons 100 and226 induced amino acid substitutions. The SNP at codon136 was a silent mutation that does not induce any aminoacid change. The genotype and allele frequencies weredetermined for each of the SNPs.
