Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats.
- Author:
Hanseul OH
1
;
Meejung AHN
;
Yoh MATSUMOTO
;
Shin TAEKYUN
Author Information
1. Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, Korea. shint@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
arginase-1;
experimental autoimmune myocarditis;
inducible nitric oxide synthase;
macrophage
- MeSH:
Animals;
Arginase;
Heart;
Macrophages*;
Myocarditis*;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Rats*
- From:Korean Journal of Veterinary Research
2013;53(4):225-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
