Sulpiride in Meige's Syndrome: Possible Role of Glutamate.

Author: Sang Am LEE ¹ ; Jin Soo KIM ; Jae Hoon AHN ; Kyoung Gyu CHOI
Author Information

1. Department of Neurology, Yonsei University College of Medicine, Korea.
Publication Type:Original Article
Keywords: Meige's syndrome; sulpiride; glutamate
MeSH: Adult; Aged; Basal Ganglia Diseases/*drug therapy; Corpus Striatum/metabolism; Dopamine/metabolism; Female; Glutamates/metabolism; Glutamic Acid; Human; Male; Meige Syndrome/*drug therapy/metabolism; Middle Age; Sulpiride/*therapeutic use
From:Yonsei Medical Journal 1988;29(1):62-65
CountryRepublic of Korea
Language:English
Abstract: Sulpiride, a selective antagonist for adenylate cyclase-independent dopamine receptors, was administrated to 25 patients with blepharospasm and oromandibular dystonia(Meige's syndrome). Of the 25, 7 patients (28%) exhibited marked and lasting improvement with sulpiride and 12 patients (48%) showed mild or transient improvement. This favorable therapeutic response to sulpiride suggests that striatal glutamate underactivity may play a role in the pathophysiology of Meige's syndrome as a primary or secondary defect.