The effects of flavanoid on the treatment of hepatopulmonary syndrome.
10.4174/jkss.2013.85.5.219
- Author:
Talha ATALAY
1
;
Murat CAKIR
;
Ahmet TEKIN
;
Tevfik KUCUKKARTALLAR
;
Suleyman KARGIN
;
Adil KARTAL
;
Adnan KAYNAK
Author Information
1. Department of General Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. drmuratcakir@hotmail.com
- Publication Type:Original Article
- Keywords:
Hepatopulmonary syndrome;
Flavanoid;
Liver;
Lung
- MeSH:
Animals;
Anoxia;
Capillaries;
Contracts;
Dilatation;
Diosmin;
Fibrosis;
Follow-Up Studies;
Gases;
Hepatopulmonary Syndrome*;
Jaundice, Obstructive;
Ligation;
Liver;
Liver Failure;
Lung;
Oxygen;
Rats;
Veins
- From:Journal of the Korean Surgical Society
2013;85(5):219-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide. METHODS: Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats' livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated. RESULTS: It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid. CONCLUSION: We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.
