Photochemotherapy-induced Lentigines on a Vitiliginous Patch Electron Microscopic Observations.
- Author:
Kwang Hoon LEE
1
;
Dong Sik BANG
;
Won Soo LEE
Author Information
- Publication Type:Case Reports
- Keywords: Vitiligo; photochemotherapy; lentigines; coagulative necrosis; apoptosis
- MeSH: Case Report; Child; Human; Lentigo/*etiology/pathology; Male; Melanocytes/ultrastructure; Microscopy, Electron; PUVA Therapy/*adverse effects; Vitiligo/drug therapy
- From:Yonsei Medical Journal 1988;29(1):66-71
- CountryRepublic of Korea
- Language:English
- Abstract: Patients with vitiligo seem be less prone to the development of lentigines as a side effect of long-term photochemotherapy than do psoriatics. An 8-year-old boy who had a vitiliginous patch on his left thigh, had been receiving photochemotherapy since he was 2 years old. At the age of 3, multiple star-shaped brownish macules developed at the site of treatment. Photochemotherapy was continued until the patient was 6 year old, at which time no improvement in the vitiligo was seen, so photochemotherapy was discontinued. Now 2 years after treatment the lentigines still persist. On electron microscopic examination, the melanocytes showed two patterns of cell death: coagulative necrosis and apotosis together with atypical cytoplasmic and melanosomal alterations.
