Increased Frequency of Apolipoprotein E4 Genotype in Childhood Minimal Change Nephrotic Syndrome (MCNS).
- Author:
Sung Do KIM
1
;
Young Min BAE
;
Byoung Soo CHO
;
Yoe Won CHO
;
Il Soo KIM
Author Information
1. Department of Pediatrics, School of Medicine, Kyunghee University, Korea.
- Publication Type:Original Article
- Keywords:
apolipoprotein E (apo-E);
Polymorphism;
Minimal Change Nephrotic Syndrome (MCNS);
IgA nephropathy (IgAN)
- MeSH:
Alleles;
Apolipoprotein E4*;
Apolipoproteins E;
Apolipoproteins*;
Blood Donors;
Child;
DNA;
Gene Frequency;
Genotype*;
Humans;
Immunoglobulin A;
Leukocytes;
Nephrosis, Lipoid*
- From:Journal of the Korean Society of Pediatric Nephrology
2001;5(2):87-99
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. MATERIALS AND METHOD: 43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared from peripheral blood leukocytes according to standard procedures. RESULTS: As compared with control group, e4 allele frequency was significantly increased in MCNS (P<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group. CONCLUSION: We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid dministration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs.
