Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma.
10.3343/alm.2016.36.6.583
- Author:
Kyung Ho JEONG
1
;
Young Jin SONG
;
Jin Yeong HAN
;
Ki Uk KIM
Author Information
1. Department of Neurosurgery, Medical Science Research Center, College of Medicine, Dong-A University, Busan, Korea. kukim@donga.ac.kr
- Publication Type:Original Article
- Keywords:
High-grade astrocytoma;
Chromosome;
EGFR amplification;
Peritumoral edema
- MeSH:
Adult;
Aged;
Astrocytoma/diagnostic imaging/mortality/*pathology;
Brain Neoplasms/diagnostic imaging/mortality/*pathology;
Chromosome Aberrations;
Chromosomes, Human, Pair 7;
Edema/diagnostic imaging/pathology;
Female;
Humans;
In Situ Hybridization, Fluorescence;
Kaplan-Meier Estimate;
Karyotype;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Neoplasm Grading;
Prognosis;
Receptors, Vascular Endothelial Growth Factor/metabolism;
Tumor Cells, Cultured;
Young Adult
- From:Annals of Laboratory Medicine
2016;36(6):583-589
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of the study is to reveal the association of cytogenetic compltyexi and peritumoral edema volume (PTEV) and its prognostic significance in high-grade astrocytoma patients by culturing patient tumor cells. METHODS: Twenty-seven high-grade astrocytoma patients were divided into three groups according to karyotype complexity: normal, non-complex karyotype (NCK), and complex karyotype (CK). Endothelial growth factor receptor (EGFR) amplification was detected by FISH, and its association with chromosome 7 abnormalities was analyzed. Mean PTEV of each group was compared by ANOVA to evaluate the relationship between PTEV and cytogenetic complexity. RESULTS: The PTEV of patients in normal (n=6), NCK (n=8), and CK (n=13) groups were 24.52±17.73, 34.26±35.04, and 86.31±48.7 cm3, respectively (P=0.005). Ten out of 11 patients with EGFR amplification showed abnormalities in chromosome 7. The mean PTEV of EGFR-amplified and non-amplified groups were 80.4±53.7 and 41.3±37.9 cm3, respectively (P=0.035). The average survival of patients with PTEV less than 90 cm3 was 30.52±26.11 months, while in patients with PTEVs over or equal to 90 cm3, it was 10.83±5.53 months (P=0.007). CONCLUSIONS: The results show an association of complex karyotype with the PTEV of high-grade astrocytoma. EGFR amplification plays a significant role in the formation of peritumoral edema, causing PTEV to increase, which is related with survival. This implies that cytogenetic karyotype can be applied as a prognostic factor.
