Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis.
10.3343/alm.2016.36.6.590
- Author:
Hyun Suk YANG
1
;
Mina HUR
;
Hanah KIM
;
Laura MAGRINI
;
Rossella MARINO
;
Salvatore DI SOMMA
Author Information
1. Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea. dearmina@hanmail.net
- Publication Type:Brief Communication
- Keywords:
sST2;
Sepsis;
Echocardiography;
Left ventricular ejection fraction;
Diastolic filling
- MeSH:
Aged;
Aged, 80 and over;
Biomarkers/blood;
Blood Pressure/physiology;
C-Reactive Protein/analysis;
Calcitonin/blood;
Echocardiography, Doppler;
Female;
Humans;
Interleukin-1 Receptor-Like 1 Protein/*blood;
Male;
Middle Aged;
Sepsis/diagnostic imaging/metabolism/*physiopathology;
Ventricular Function, Left/physiology
- From:Annals of Laboratory Medicine
2016;36(6):590-594
- CountryRepublic of Korea
- Language:English
-
Abstract:
Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown. We explored whether sST2 serum concentration reflects either systolic or diastolic dysfunction as measured by Doppler echocardiography. In a total of 127 patients with sepsis, correlations between sST2 and blood pressure, left ventricular (LV) ejection fraction, LV diastolic filling (ratio of early transmitral flow velocity to early diastolic mitral annulus velocity), and resting pulmonary arterial pressure were evaluated. Correlations between sST2 and other sepsis biomarkers (high-sensitivity C-reactive protein [hs-CRP] and procalcitonin) were also examined. sST2 showed a moderate correlation with mean arterial pressure (r=-0.3499) but no correlation with LV ejection fraction, diastolic filling, or resting pulmonary hypertension. It showed moderate correlations with hs-CRP and procalcitonin (r=0.2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis.
