A Canine Model of Tracheal Stenosis Using Nd-YAG Laser.
- Author:
Jhin Gook KIM
1
;
Gee Young SUH
;
Man Pyo CHUNG
;
O Jung KWON
;
Soo Won SUH
;
Ho Joong KIM
Author Information
- Publication Type:Original Article
- Keywords: Animal model; Upper airway Obstruction; Bronchoscopy
- MeSH: Animals; Bronchoscopy; Cartilage; Constriction, Pathologic; Dogs; Dyspnea; Fibrosis; Granulation Tissue; Laser Coagulation; Lasers, Solid-State*; Learning; Microscopy; Models, Animal; Primary Health Care; Respiratory Insufficiency; Respiratory Sounds; Trachea; Tracheal Stenosis*; Weight Loss
- From:Tuberculosis and Respiratory Diseases 2002;52(1):54-61
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: Tracheal stenosis is an urgent but uncommon disease. Therefore, primary care clinicians have limited clinical experience. Animal models of a tracheal stenosis can be used conveniently for the learning, teaching, and developing new diagnostic and therapeutic modalities for tracheal stenosis. Recently, a canine model of a tracheal stenosis was developed using a Nd-YAG laser. To describe the methods and results of developed animal model, we performed this study. METHODS: Six Mongrel dogs were generally anesthetized and the anterior 180 degree of tracheal cartilage of the animal was photo-coagulated using a Nd-YAG laser. The animals were bronchoscopically evaluated every week for 4 weeks and a pathologic evaluation was also made. RESULTS: Two weeks after the laser coagulation, the trachea began to stenose and the stenosis progressed through 4 weeks. All animals suffered from shortness of breath, wheezing, and weight loss in the 3 weeks after the laser treatment, and two died of respiratory failure just before the fourth week. The gross pathologic findings showed the loss of cartilage and a dense fibrosis, which resulted in a fibrous stricture of the trachea. Microscopy also showed that the fibrous granulation tissue replaced destroyed cartilage. CONCLUSION: The canine model can assist in the understanding and development of new diagnostic and therapeutic modalities for tracheal stenosis.
