The Expression of Caspase 3 and p21 in Renal Cell Carcinoma.
- Author:
Jeong Kyun YEO
1
;
Duck Ki YOON
;
Cheol Yong YOON
;
Cheol Han KIM
Author Information
1. Department of Urology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Caspase 3;
Renal cell carcinoma;
Prognosis;
Apoptosis
- MeSH:
Animals;
Apoptosis;
Carcinoma, Renal Cell*;
Caspase 3*;
Humans;
Mice;
Prognosis;
Survival Rate
- From:Korean Journal of Urology
2002;43(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The objective of this study was to evaluate the Caspase 3 and p21 expression level and to understand the correlation between Caspase 3 expression and the clinical factors in renal cell carcinoma. MATERIALS AND METHODS: Forty-two patients with renal cell carcinoma were enrolled in this study. Immunohistochemical staining of Caspase 3 and p21 was performed in formalin-fixed and paraffin-embedded tissue sections using rabbit polyclonal antibody (Caspase 3) and mouse antibody (p21). The Caspase 3 and p21 expression levels were compared with the TNM stage, Fuhrman grade, pathological type and survival rates. RESULTS: The Caspase 3 expression level correlated only with the Fuhrman grade (p=0.017). There was no significant correlation between the Caspase 3 and p21 expression level. The prognostic values did not correlate with the Caspase 3 and p21 expression level. CONCLUSIONS: The prognostic value of the Caspase 3 expression level in renal cell carcinoma was insufficient. The relationship between Caspase 3 and p21 was not proven in renal cell carcinoma, and new factors may be implicated with Caspase 3.
