Ahmed Valve Implantation with Adjunctive Mitomycin C and 5-Fluorouracil: Outcomes at 2 Years.
10.3341/jkos.2011.52.12.1470
- Author:
Sung Hyup LIM
1
;
Won Moon SEO
;
Jun Jeong PARK
;
Seong Uk YUN
Author Information
1. Department of Ophthalmology, Dongkang General Hospital, Ulsan, Korea. Medi94@naver.com
- Publication Type:Original Article
- Keywords:
Ahmed valve implantation;
Neovascular glaucoma;
Success rate;
MMC;
5-FU
- MeSH:
Endophthalmitis;
Eye;
Fluorouracil;
Follow-Up Studies;
Glaucoma;
Glaucoma, Neovascular;
Humans;
Intraocular Pressure;
Mitomycin
- From:Journal of the Korean Ophthalmological Society
2011;52(12):1470-1477
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the outcomes of Ahmed valve implantation in neovascular glaucoma patients who received intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU) after 24 months of follow-up. METHODS: A total of 40 eyes from 40 patients with neovascular glaucoma who received antiglaucomatous medication without previous glaucoma surgery were included in the present study. The patients were divided into 2 groups. The control group (20 eyes) underwent Ahmed valve implantation only and the study group (20 eyes) underwent Ahmed valve implantation and received intraoperative MMC and postoperative 5-FU. Failure was defined as the first occurrence of any of the following: 1) the first of 3 consecutive visits where intraocular pressure (IOP) was over 18 mmHg; 2) 20% IOP reduction from baseline; 3) the final number of topical medications was not reduced by at least two from baseline; 4) the need for additional surgery; or 5) the occurrence of a serious complication. RESULTS: In the control group, the cumulative success rate was 19.1% at 24 months. The cumulative success rate in the study group was 43.7% at 24 months. Serious complications such as endophthalmitis, valve exposure, or prolonged hypotony were not observed. CONCLUSIONS: The adjunctive use of intraoperative MMC and postoperative 5-FU with Ahmed valve implantation resulted in a high success rate and good IOP control and did not cause serious complications during the follow-up period.
