Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis.
10.3346/jkms.2017.32.9.1468
- Author:
Myung Hyun CHO
1
;
Soo Nyung KIM
;
Hye Won PARK
;
Sochung CHUNG
;
Kyo Sun KIM
Author Information
1. Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea. 19890009@kuh.ac.kr
- Publication Type:Meta-Analysis ; Randomized Controlled Trial ; Original Article
- Keywords:
Acute Kidney Injury;
Contrast Media;
Meta-Analysis;
Vitamin E
- MeSH:
Acute Kidney Injury*;
Contrast Media;
Creatinine;
Glomerular Filtration Rate;
Humans;
Incidence;
Odds Ratio;
Population Characteristics;
Vitamin E*;
Vitamins*
- From:Journal of Korean Medical Science
2017;32(9):1468-1473
- CountryRepublic of Korea
- Language:English
-
Abstract:
Several clinical studies have proposed a protective role for vitamin E (α-tocopherol) against contrast-induced acute kidney injury (CIAKI). The aim of study was to assess the effects of vitamin E for the prevention of CIAKI. A systematic review and meta-analysis was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials (RCTs) reporting the effects of vitamin E on CIAKI development and measurements of renal function were included. Four trials including 623 participants were analyzed in the meta-analysis. All participants received intravenous hydration in addition to vitamin E or placebo. The incidence of the vitamin E group (5.8%) was lower than that of the control group (15.4%). Compared with the control, vitamin E significantly reduced the risk ratio (RR) of CIAKI by 62% (0.38; 95% confidence interval [CI], 0.22, 0.63; P < 0.010). In addition, vitamin E reduced serum creatinine (SCr) increase after contrast administration (standardized mean difference [SMD], −0.27; 95% CI, −0.49, −0.06; P = 0.010). However, changes in glomerular filtration rate (GFR) after contrast administration were not significantly different between vitamin E and the control group (SMD, 0.21; 95% CI, −0.01, 0.43; P = 0.060). Heterogeneity within the available trials was not observed. Our meta-analysis provides evidence that vitamin E plus hydration significantly reduced the risk of CIAKI in patients with renal impairment compared with hydration alone.
