Increased Level of Basophil CD203c Expression Predicts Severe Chronic Urticaria.
10.3346/jkms.2014.29.1.43
- Author:
Young Min YE
1
;
Eun Mi YANG
;
Hye Soo YOO
;
Yoo Seob SHIN
;
Seung Hyun KIM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Chronic Urticaria;
Basophil Activation;
CD203c Protein, Human
- MeSH:
Adult;
Autoantibodies/blood;
Basophils/*immunology;
Female;
Flow Cytometry;
Humans;
Immunoglobulin E/blood/immunology;
Male;
Phosphoric Diester Hydrolases/biosynthesis/*immunology;
Pyrophosphatases/biosynthesis/*immunology;
Receptors, IgE/biosynthesis;
Urticaria/*immunology
- From:Journal of Korean Medical Science
2014;29(1):43-47
- CountryRepublic of Korea
- Language:English
-
Abstract:
Increased FcepsilonR1alpha expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c expression level and clinical disease activity in CU patients. To investigate whether the increase of basophil activation is associated with the disease activity of CU, we measured basophil CD203c expression using a tricolor flow cytometric method in 82 CU patients and 21 normal controls. The relationship between the percentage of CD203c-expressing basophils and clinical parameters was analyzed. The mean basophil CD203c expression was significantly higher in CU patients than in healthy controls (57.5% vs 11.6%, P < 0.001). The basophil CD203c expression in severe CU patients was significantly higher than in non-severe CU (66.5% +/- 23.3% vs 54.0% +/- 23.3%, P = 0.033). Multiple logistic regression analysis indicated that both > or = 72% basophil CD203c expression and urticaria activity score (UAS)> or = 13 were significant predictors of severe CU (P = 0.005 and P = 0.032, respectively). These findings suggest that the quantification of basophil activation with CD203c at baseline may be used as a potential predictor of severe CU requiring another treatment option beyond antihistamines.
