Serum Magnesium Level Is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study.
10.3346/jkms.2014.29.1.84
- Author:
Sae Jeong YANG
1
;
Soon Young HWANG
;
Sei Hyun BAIK
;
Kwan Woo LEE
;
Moon Suk NAM
;
Yong Soo PARK
;
Jeong Taek WOO
;
Young Seol KIM
;
Sunmin PARK
;
So Young PARK
;
Chang Hoon YIM
;
Hyun Koo YOON
;
Sung Hoon KIM
Author Information
1. Department of Internal Medicine, Daerim St. Mary's Hospital, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Diabetes, Gestational;
Serum Magnesium;
Hypomagnesaemia;
Prediabetes;
Diabetes Mellitus;
Type 2
- MeSH:
Adult;
Blood Glucose;
Cohort Studies;
Diabetes Mellitus, Type 2/*blood/diagnosis;
Diabetes, Gestational/*blood;
Female;
Glucose Intolerance/*blood;
Glucose Tolerance Test;
Humans;
Insulin Resistance;
Magnesium/*blood;
Postpartum Period/*blood;
Prediabetic State/diagnosis;
Pregnancy;
Prospective Studies;
Republic of Korea;
Risk Factors
- From:Journal of Korean Medical Science
2014;29(1):84-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gestational diabetes mellitus (GDM) is a strong predictor of postpartum prediabetes and transition to overt type 2 diabetes (T2DM). Although many reports indicate that low magnesium is correlated with deteriorated glucose tolerance, the association between postpartum serum magnesium level and the risk for T2DM in women with a history of GDM has not been evaluated. We analyzed postpartum serum magnesium levels and development of prediabetes and T2DM in women with prior GDM according to American Diabetes Association (ADA) criteria using the Korean National Diabetes Program (KNDP) GDM cohort. During a mean follow-up of 15.6+/-2.0 months after screening, 116 women were divided into three groups according to glucose tolerance status. Ultimately, eight patients (6.9%) were diagnosed with T2DM, 59 patients (50.9%) with prediabetes, and 49 patients (42.2%) with normal glucose tolerance (NGT) after follow-up. The T2DM group had the lowest serum magnesium level (0.65 [0.63-0.68] mM/L) in the postpartum period, but there was no significant difference between the prediabetes group (0.70 [0.65-0.70] mM/L) and the NGT group (0.70 [0.65-0.70] mM/L) (P=0.073) Multiple logistic regression analysis showed that postpartum HOMA-IR was a significant predictor of both prediabetes and T2DM. Moreover, we found that postpartum serum magnesium level was also a possible predictor for T2DM development. Serum magnesium level in the postpartum period may be a possible predictor for T2DM development in women with a history of GDM.
