Optimal Time to Start Peripheral Blood Stem Cell Collection in Children with High-Risk Solid Tumors.
10.3346/jkms.2014.29.1.110
- Author:
Ki Woong SUNG
1
;
Hee Won CHUEH
;
Na Hee LEE
;
Dong Hwan KIM
;
Soo Hyun LEE
;
Keon Hee YOO
;
Hong Hoe KOO
;
Eun Suk KANG
;
Dae Won KIM
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
High-Dose Chemotherapy;
Autologous Stem Cell Transplantation;
Peripheral Blood Stem Cell Collection
- MeSH:
Adolescent;
Adult;
Antigens, CD34/metabolism;
Antineoplastic Agents/therapeutic use;
Child;
Child, Preschool;
Female;
Granulocyte Colony-Stimulating Factor/therapeutic use;
Hematopoietic Stem Cell Transplantation/*methods;
Hematopoietic Stem Cells/*cytology;
Humans;
Infant;
Leukocyte Count;
Male;
Neoplasms/*blood/drug therapy;
Transplantation, Autologous;
Young Adult
- From:Journal of Korean Medical Science
2014;29(1):110-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
In order to clarify the optimal timing for peripheral blood stem cell (PBSC) collection, PBSC collection records of 323 children who were scheduled to undergo autologous stem cell transplantation from two study periods differing in the timing of PBSC collection were analyzed. In the early study period (March 1998 to August 2007, n=198), PBSC collection was initiated when the peripheral WBC count exceeded 1,000/microL during recovery from chemotherapy. Findings in this study period indicated that initiation of PBSC collection at a higher WBC count might result in a greater CD34+ cell yield. Therefore, during the late study period (September 2007 to December 2012, n=125), PBSC collection was initiated when the WBC count exceeded 4,000/microL. Results in the late study period validated our conclusion from the early study period. Collection of a higher number of CD34+ cells was associated with a faster hematologic recovery after transplant in the late study period. Initiation of PBSC collection at WBC count > 4,000/microL was an independent factor for a greater CD34+ cell yield. In conclusion, PBSC collection at a higher WBC count is associated with a greater CD34+ cell yield, and consequently a faster hematologic recovery after transplant.
