Computed Tomography Guided Percutaneous Injection of a Mixture of Lipiodol and Methylene Blue in Rabbit Lungs: Evaluation of Localization Ability for Video-Assisted Thoracoscopic Surgery.
10.3346/jkms.2014.29.1.129
- Author:
Kwang Nam JIN
1
;
Kyung Won LEE
;
Tae Jung KIM
;
Yong Sub SONG
;
Dong Il KIM
Author Information
1. Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
- Publication Type:Original Article ; Evaluation Studies ; Research Support, Non-U.S. Gov't
- Keywords:
Lung;
Ethiodized Oil;
Methylene Blue;
Tomography, X-Ray Computed;
Radiology, Interventional
- MeSH:
Animals;
Ethiodized Oil/*administration & dosage;
Fluoroscopy;
Injections, Subcutaneous;
Lung/*radiography/surgery;
Methylene Blue/*administration & dosage;
Preoperative Care;
Rabbits;
Solitary Pulmonary Nodule/*surgery;
Staining and Labeling/methods;
Thoracic Surgery, Video-Assisted/*methods;
Thoracoscopy/methods;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2014;29(1):129-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
Preoperative localization is necessary prior to video assisted thoracoscopic surgery for the detection of small or deeply located lung nodules. We compared the localization ability of a mixture of lipiodol and methylene blue (MLM) (0.6 mL, 1:5) to methylene blue (0.5 mL) in rabbit lungs. CT-guided percutaneous injections were performed in 21 subjects with MLM and methylene blue. We measured the extent of staining on freshly excised lung and evaluated the subjective localization ability with 4 point scales at 6 and 24 hr after injections. For MLM, radio-opacity was evaluated on the fluoroscopy. We considered score 2 (acceptable) or 3 (excellent) as appropriate for localization. The staining extent of MLM was significantly smaller than methylene blue (0.6 vs 1.0 cm, P<0.001). MLM showed superior staining ability over methylene blue (2.8 vs 2.2, P=0.010). Excellent staining was achieved in 17 subjects (81%) with MLM and 8 (38%) with methylene blue (P=0.011). An acceptable or excellent radio-opacity of MLM was found in 13 subjects (62%). An appropriate localization rate of MLM was 100% with the use of the directly visible ability and radio-opacity of MLM. MLM provides a superior pulmonary localization ability over methylene blue.
