Localized Thymic Amyloidosis Presenting with Myasthenia Gravis: Case Report.
10.3346/jkms.2014.29.1.145
- Author:
Seung Myoung SON
1
;
Yong Moon LEE
;
Si Wook KIM
;
Ok Jun LEE
Author Information
1. Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea. ok5218@hanmail.net
- Publication Type:Case Reports
- Keywords:
Amyloidosis;
Thymus;
Mediastinum;
Myasthenia Gravis
- MeSH:
Amyloidosis/complications/*radiography/*surgery;
Calcinosis/*radiography/*surgery;
Female;
Humans;
Immunoglobulin kappa-Chains/immunology;
Immunoglobulin lambda-Chains/immunology;
Mediastinum/radiography/surgery;
Middle Aged;
Myasthenia Gravis/*complications;
Radiography, Thoracic;
Thymectomy;
Thymus Gland/radiography/surgery;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2014;29(1):145-148
- CountryRepublic of Korea
- Language:English
-
Abstract:
A mediastinal mass was incidentally found on chest radiography in a 46-yr-old woman who had had myasthenia gravis (MG) for 2 months. Computed tomography revealed a 4-cm in size, well-defined, and lobulating mass with nodular calcification that was located in the thymus. Microscopically, the mass consisted of diffuse amorphous eosinophilic materials. These deposits exhibited apple-green birefringence under polarized light microscopy after Congo red staining. Immunohistochemical analysis revealed that they were positive for both kappa and lambda light chains and negative for amyloid A. A diagnosis of localized primary thymic amyloidosis was finally made. After thymectomy, the symptoms of MG were controlled with reduced corticosteroid requirements. Localized thymic amyloidosis associated with MG has not been reported to date.
