IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma.
- Author:
Ji Young PARK
1
;
Misun CHOE
;
Yuna KANG
;
Sang Sook LEE
Author Information
1. Department of Pathology, Keimyung University School of Medicine, Daegu, Korea. msc@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, renal cell;
IMP3;
Tumor suppressor protein p53;
Ki-67;
Neoplasm metastasis
- MeSH:
Carcinoma, Renal Cell*;
Humans;
Insulin-Like Growth Factor II;
Neoplasm Metastasis;
Nephrectomy;
Retrospective Studies;
Tumor Suppressor Protein p53
- From:Korean Journal of Pathology
2014;48(2):108-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes. METHODS: We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed. RESULTS: Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival. CONCLUSIONS: IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.
