Mitogen-activated Protein Kinases in Inflammation.
10.4167/jbv.2012.42.3.189
- Author:
Zahid MANZOOR
1
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Review
- Keywords:
MAPKs;
Inflammation
- MeSH:
Arthritis, Rheumatoid;
Cytokines;
Extracellular Signal-Regulated MAP Kinases;
Humans;
Inflammation;
Mitogen-Activated Protein Kinases;
p38 Mitogen-Activated Protein Kinases;
Phosphotransferases;
Shock, Septic
- From:Journal of Bacteriology and Virology
2012;42(3):189-195
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective response of host against microbial infection. Controlled inflammation is beneficial and necessary for host defense while uncontrolled inflammatory response results in inflammatory diseases such as septic shock, rheumatoid arthritis and cancer. The MAPK family consists of three subfamilies; the extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases (JNKs), and the p38 MAPKs. MAPKs are involved in transmitting extracellular signals to nucleus which leads to gene regulation. In this review, we summarize the current knowledge of ERK1/2, JNKs, and p38 MAPK members and their roles in inflammation.
