A Study of Factors Related to the Course of Graves' Ophthalmopathy.
10.3341/jkos.2011.52.3.255
- Author:
Joong Hun KIM
1
;
Tae Soo LEE
Author Information
1. Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. tsoooo@hanmail.net
- Publication Type:Original Article
- Keywords:
Graves' ophthalmopathy;
Risk factor;
Severity
- MeSH:
Female;
Follow-Up Studies;
Humans;
Retrospective Studies;
Risk Factors;
Smoke;
Smoking;
Thyroid Function Tests
- From:Journal of the Korean Ophthalmological Society
2011;52(3):255-260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the risk factors related to the course of Graves' ophthalmopathy (GO). METHODS: This is a retrospective study of 125 patients who were referred to our clinic and diagnosed with GO from March 2006 to August 2008. Ophthalmic examinations and a thyroid function test including TSI were performed at the time of diagnosis and every 3 months after diagnosis. All patients were classified as having a mild or severe course of GO, according to Clinical Activity Score (CAS) and NOSPECS classifications. RESULTS: This statistical analysis of each group revealed that female sex (p = 0.04), age (p = 0.0004), smoking (p = 0.003), and high TSI level (p = 0.009) were significant factors for severe course of GO at the time of diagnosis. TSI levels at each of the 3 visits during the follow-up were significantly higher in patients with a severe course of GO, as compared to patients with a mild course of GO (first visit: p = 0.003, second visit: p = 0.002, third visit: p = 0.006). CONCLUSIONS: Female sex, age, smoking, and high TSI level appear to be the risk factors that can predict the severity of GO at the time of diagnosis. Additionally, the TSI level can reflect the severity of GO during the follow-up periods.
