Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and -D in Resected Non-Small Cell Lung Cancer.
- Author:
Yoon Ho KO
1
;
Chan Kwon JUNG
;
Myung Ah LEE
;
Jae Ho BYUN
;
Jin Hyoung KANG
;
Kyo Young LEE
;
Keon Hyun JO
;
Young Pil WANG
;
Young Seon HONG
Author Information
1. Division of Oncology, Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. y331@ catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Carcinoma;
Non-small-cell lung;
Vascular endothelial growth factor;
Lymphangiogenesis;
Neoplasm metastasis
- MeSH:
Carcinoma, Non-Small-Cell Lung;
Humans;
Lung;
Lymph Nodes;
Lymphangiogenesis;
Multivariate Analysis;
Neoplasm Metastasis;
Receptors, Vascular Endothelial Growth Factor;
Recurrence;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor C;
Vascular Endothelial Growth Factor D;
Vascular Endothelial Growth Factor Receptor-3;
Vascular Endothelial Growth Factors
- From:Cancer Research and Treatment
2008;40(3):133-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play important roles in lymphangiogenesis via the VEGF receptor 3 (VEGFR-3). We sought to determine whether VEGF-C, VEGF-D and VEGFR-3 are involved in the clinical outcomes of patients with resected NSCLC. MATERIALS AND METHODS: Using immunohistochemical staining, we investigated the protein expressions of VEGF-C, VEGF-D and VEGFR-3 in the tissue array specimens from patients who underwent resection for NSCLC. The immunoreactivity for p53 was also examined. The clinicopathological implications of these molecules were statistically analyzed. RESULTS: Analysis of a total of 118 specimens showed that VEGF-C, VEGF-D and their co-expression were significantly associated with more advanced regional lymph node metastasis (p=0.019, p=0.044 and p=0.026, respectively, N2 versus N0 and N1). A VEGFR-3 expression had a strong correlation with peritumoral lymphatic invasion (p=0.047). On the multivariate analysis for survival and recurrence, pathologic N2 lymph node metastasis was the only independent prognostic factor, but none of the investigated molecules showed any statistical correlation with recurrence and survival. CONCLUSIONS: The present study revealed that high expressions of VEGF-C and VEGF-D were strongly associated with more advanced regional lymph node metastasis in patients with resected NSCLC.
