Effect of Recombinant Human Granulocyte Colony-Stimulating Factor to Neutropenic Low Birth Weight Infants of Mothers with Preeclampsia.
- Author:
Bin CHO
1
;
In Kyung SUNG
;
Hack Ki KIM
Author Information
1. Department of Pediatrics, St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Granulocyte colony-stimulating factor(G-CSF);
Neutropenia;
Low birth weight infant
- MeSH:
Bacterial Infections;
Birth Weight;
Bone Marrow;
Child;
Cross Infection;
Gestational Age;
Granulocyte Colony-Stimulating Factor*;
Granulocytes*;
Humans*;
Infant*;
Infant, Low Birth Weight*;
Infant, Newborn;
Injections, Subcutaneous;
Mothers*;
Neutropenia;
Neutrophils;
Pre-Eclampsia*;
Sepsis
- From:Korean Journal of Pediatric Hematology-Oncology
1998;5(1):30-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Almost 50% of infants born to mothers with preeclampsia have neutropenia and are at increased risk of having early-onset sepsis and nosocomial infection. In neutropenic children, recombinant human granulocyte colony-stimulating factor(rhG-CSF) increase circulating neutrophils and bone marrow neutrophil storage pools, improves neutrophil function, and results in fewer bacterial infections. We examined circulating neutrophil counts after administration of rhG-CSF to neutropenic neonates of mothers with preeclampsia. METHOD: Subjects were selected from premature(gestational age<36 weeks) and low birth weight infants(<2,500 g) born with preeclampsia at the St. Mary's Hospital between January, 1996 and July, 1997. The rhG-CSF was administered as an subcutaneous injection, 10 microgram/kg per dose. The first dose was given before 24 hours of age, and the medication was given at 24-hour intervals for three doses. We selected control infants with matched subjects for gestational age and birth weight with normal neutrophil count. Results: 1) Initial WBC counts of the study infants, obtained at birth-day, were not significantly different from the WBCs of study infants(t-test. P>0.05). 2) Absolute neutrophil counts(ANCs) in rhG-CSF-treated infants at 24, 48 and 72 hours of age were significantly higher than initila ANCs at birth(P<0.05). 3) ANCs in control group at 24 and 48 hours of age were not significantly different from initial ANCs at birth(t-test, P>0.05), but significantly lower at 72 and 96 hour of age(t-test, P<0.05). 4) ANCs in rhG-CSF treated infants at 24 and 48 hours of age were significantly higher than those in control group(P<0.05), but at 72 and 96 hours of age, there were not significant difference between ANCs in treated infants and those in control group(P<0.05). Conclusoin: rhG-CSF promote a rapid increase in circulating neutrophils in netropenic low birth weight infants of mothers with preeclampsia.
