Effect of Intraperitoneal and Intravesical Bacillus Calmette-Guerin on Bladder Carcinogenesis in Rats Induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
- Author:
Kwang Myung KIM
1
;
Young Kyoon KIM
Author Information
1. Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
bladder tumor;
BCG;
BBN
- MeSH:
Administration, Intravesical;
Animals;
Bacillus*;
Carcinogenesis*;
Carcinoma, Transitional Cell;
Immunotherapy;
Incidence;
Injections, Intraperitoneal;
Mycobacterium bovis;
Rats*;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
1988;29(3):351-365
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effects of intraperitoneal injection and intravesical instillation of viable Bacillus Calmette-Guerin(BCG) as an inhibitor in the development of experimental bladder tumors, were examined in rats administered with N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN). A single intraperitoneal injection of BCG at the initiation of BBN administration inhibited significantly the occurrence of transitional cell carcinoma of the urinary bladder, while the same intraperitoneal BCG 2 weeks prior to the administration of BBN did not significantly suppress the carcinogenesis. A series of additional intravesical BCG instillation of different doses and durations to the initial intraperitoneal BCG did not potentiate significantly the antitumor effect by BCG, however, there was a considerable reduction of tumor incidence. The above results suggest that viable BCG immunotherapy alter favorably the course of the experimental bladder cancer in rats, and the routes, intervals and doses of BCG would critically effect the anti-tumor activity, accordingly.
