Prognostic Impact of Changes in Adipose Tissue Areas after Colectomy in Colorectal Cancer Patients.
10.3346/jkms.2016.31.10.1571
- Author:
Eun Kyung CHOE
1
;
Kyu Joo PARK
;
Seung Bum RYOO
;
Sang Hui MOON
;
Heung Kwon OH
;
Eon Chul HAN
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. kjparkmd@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal Neoplasms;
Obesity;
Adipose Tissue;
Prognosis
- MeSH:
Adipose Tissue*;
Body Mass Index;
Chemotherapy, Adjuvant;
Colectomy*;
Colorectal Neoplasms*;
Disease-Free Survival;
Drug Therapy;
Humans;
Intra-Abdominal Fat;
Multivariate Analysis;
Obesity;
Prognosis;
Subcutaneous Fat
- From:Journal of Korean Medical Science
2016;31(10):1571-1578
- CountryRepublic of Korea
- Language:English
-
Abstract:
There have been few studies assessing the changes in the body components of patients after colectomy in colorectal cancer (CRC). The purpose of this study was to verify the trends in the adipose tissue areas of CRC patients before and after surgery and to determine their clinical relevance. Computed tomography (CT)-assessed subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) areas were recorded before and after curative resection in stage I to III CRC patients. Changes in the adipose tissue were assessed by calculating the difference in the adipose tissue area between preoperative CT and the most recent postoperative CT, which is disease-free state. Regarding obesity before surgery, there were no prognostic effect of body mass index (BMI), VAT and SAT, and 47.3% of patients had increases in VAT after colectomy. By multivariate analysis, adjusting sex, age, stage, differentiation, VAT change was the only obesity related factor to predict the prognosis, that patients who had increase in VAT after colectomy had better overall survival (HR, 0.557; 95% CI, 0.317-0.880) and disease-free survival (HR, 0.602; 95% CI, 0.391-0.927). BMI and SAT change had no significant association. In subgroup analysis of stage III CRC patients, VAT change had significance for prognosis only in patients who had adjuvant chemotherapy but not in those who did not receive postoperative chemotherapy. Increase in visceral adipose tissue after surgery is a favorable predictor of prognosis for CRC patients.
