Comparison of Helicobacter pylori Eradication Rate according to Different PPI-based Triple Therapy : Omeprazole, Rabeprazole, Esomeprazole and Lansoprazole.
- Author:
Bora KEUM
1
;
Sang Woo LEE
;
Se Yune KIM
;
Min Jeong KIM
;
Rok Son CHOUNG
;
Hyung Joon YIM
;
Yoon Tae JEEN
;
Hong Sik LEE
;
Hoon Jai CHUN
;
Soon Ho UM
;
Jai Hyun CHOI
;
Chang Duck KIM
;
Ho Sang RYU
;
Jin Hai HYUN
Author Information
1. Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea. leesw@kumc.or.kr
- Publication Type:Comparative Study ; English Abstract ; Original Article
- Keywords:
Proton pump inhibitor;
Helicobacter pylori;
Eradication rate
- MeSH:
Adult;
Anti-Infective Agents/*therapeutic use;
Anti-Ulcer Agents/*therapeutic use;
Comparative Study;
Drug Therapy, Combination;
English Abstract;
Female;
Helicobacter Infections/*drug therapy/microbiology;
*Helicobacter pylori;
Humans;
Male;
Middle Aged;
Proton Pumps/*antagonists & inhibitors
- From:The Korean Journal of Gastroenterology
2005;46(6):433-439
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Helicobacter pylori (H. pylori) is an important cause of various gastrointestinal diseases. H. pylori eradication is essential for the cure and prevention of associated diseases. Nowdays, proton pump inhibitor (PPI)-based triple therapy is the standard eradication regimen. The aims of this study were to compare the H. pylori eradication rate of different PPI-based triple therapies and to find out the factors influencing the eradication rate. METHODS: From May 2002 through Febraury 2004, H. pylori infected patients were treated with the eradication regimen based on one of the four PPIs (omeprazole, rabeprazole, esomeprazole and lansoprazole) for 1 or 2 weeks. After two weeks, drug compliance, adverse effects, and smoking history during the eradication therapy were obtained. The follow-up H. pylori test was performed 4 weeks after the completion of therapy. The data were analyzed by Chi-square test and multiple logistic regression analysis. RESULTS: Overall eradication rate was 83.5%. There was no significant difference in eradication rate among four PPIs (p=0.379). Odds ratio (OR) for omeprazole and rabeprazole was 1.15 (95% CI 0.50-2.68); for omeprazole and esomeprazole, OR 1.63 (95% CI 0.68-3.89); and for omeprazole and lansoprazole, OR 1.13 (95% CI 0.50-2.56). Smoking habit, site of ulcer, and the duration of therapy affected the eradication rate significantly. CONCLUSIONS: The efficacy of four different PPIs for H. pylori eradication is similar to each other. Smoking, site of ulcer, and the duration of treatment have significant effects on eradication rates.
