The Clinical Usefulness of SPIO-MRI in Detection and Staging of Hepatocellular Carcinoma.
- Author:
Kwang Cheol KOH
1
;
Hong Joo KIM
;
Won Hyeok CHOE
;
Gyung Soo CHAE
;
Moon Seok CHOI
;
Joon Hyoek LEE
;
Seung Woon PAIK
;
Jong Chul RHEE
;
Kyu Wan CHOI
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ringer@hanafos.com
- Publication Type:Original Article ; English Abstract
- Keywords:
SPIO-MRI;
3-phase dynamic helical CT;
Neoplasm/Liver/Hepatocellular carcinoma
- MeSH:
Adult;
Aged;
Carcinoma, Hepatocellular/*diagnosis;
*Contrast Media;
False Negative Reactions;
False Positive Reactions;
Female;
Ferrosoferric Oxide;
Humans;
Iron/*diagnostic use;
Liver Neoplasms/*diagnosis;
*Magnetic Resonance Imaging;
Male;
Middle Aged;
Oxides/*diagnostic use;
Tomography, Spiral Computed
- From:The Korean Journal of Hepatology
2003;9(1):17-24
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: It is still unclear whether Super Paramagnetic Iron Oxide-Magnetic Resonance Imaging (SPIO-MRI) is a clinically useful imaging modality for patients with hepatocellular carcinoma (HCC). This study searched for the clinical usefulness and limitations of SPIO-MRI with respect to tumor detection capacity, false positive and negative rate, and early recurrence rate. METHODS: From December 1999 to February 2001, 218 patients who were surgical candidates by 3-phase dynamic helical CT (3dHCT) were enrolled. We reviewed the medical records and radiologic findings, retrospectively, and postulated the post-operative pathologic findings and the early recurrences within 3 months as the standards for the true positive lesion. RESULTS: The mean number of nodules detected by SPIO-MRI was significantly more numerous than that of 3dHCT (p<0.01). Modifications of treatment strategy due to the discordant findings between SPIO-MRI and 3dHCT for tumor resectability were observed in 22 (10.1%) out of 218 patients. Early recurrences were observed in 10 patients (7.8%). The false positive and negative rates of SPIO-MRI were 6.3% and 13.3%, respectively. CONCLUSIONS: We demonstrated that the tumor detection rate of SPIO-MRI was better than that of 3dHCT. Given the relatively acceptable false positive and negative rates, SPIO-MRI could be an appropriate preoperative imaging modality for patients with HCCs.
