A Case of Recurrent Pancreatitis Induced by Trimethoprim-Sulfamethoxazole Re-Exposure.
- Author:
Tae Young PARK
1
;
Hyoung Chul OH
;
Jae Hyuk DO
Author Information
1. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. jhdo@cau.ac.kr
- Publication Type:Case Report
- Keywords:
Pancreatitis;
Drug;
Ttrimethoprim-sulfamethoxazole
- MeSH:
Adult;
Humans;
Pancreatitis;
Prostatitis;
Sulfamethoxazole;
Trimethoprim;
Urethritis;
Trimethoprim, Sulfamethoxazole Drug Combination
- From:Gut and Liver
2010;4(2):250-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 32-year-old man presented with epigastric pain. He had a previous episode of acute pancreatitis of undetermined cause 2 years earlier. The patient had taken trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily because of acute urethritis 3 days prior to admission. No definite cause of acute pancreatitis could be identified on baseline studies. A thorough history-taking revealed that the patient had an episode of acute pancreatitis while taking trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily for 2 weeks for prostatitis prior to the previous admission. Therefore, a cause-and-effect relationship between trimethoprim-sulfamethoxazole (TMP-SMX) and repeated episodes of pancreatitis was highly suggested. The patient was presumably diagnosed as TMP-SMX-induced pancreatitis. The final diagnosis was TMP-SMX-induced pancreatitis. Since drugs are rare causes of acute pancreatitis and the diagnosis of drug-induced pancreatitis is difficult to establish, we report this interesting case along with a review of medical literature.
