A Phase II Trial of Combination Chemotherapy with Cisplatin & Etoposide in Small Cell Lung Cancer.
10.4046/trd.1994.41.6.632
- Author:
Eun Mee CHEON
;
Hyung Gun KIM
;
Tae Young SON
;
Young Jin YUH
;
Sang Goo LEE
;
Choon Taek LEE
;
Young Hwan KIM
;
Jhin Oh LEE
;
Tae Woong KANG
- Publication Type:Original Article
- Keywords:
Cisplatin;
Etoposide;
Combination chemotherapy;
Small cell lung cancer
- MeSH:
Brain;
Cisplatin*;
Cyclophosphamide;
Drug Therapy;
Drug Therapy, Combination*;
Etoposide*;
Humans;
Small Cell Lung Carcinoma*;
Thorax
- From:Tuberculosis and Respiratory Diseases
1994;41(6):632-643
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The objective responses of cisplatin and etoposide (PVP) combination chemotherapy as second-line therapy following CAV was high (40~50%) and, in several reports, PVP yields survival results that are at least as good as those obtained with cyclophosphamide or doxorubicin-based regimens and with less host-related toxicity in chemotherapy-naive patients. We conducted a phase II study to evaluate the effect of a combination of cisplatin and etoposide as a first-line therapy in patients with small cell lung cancer. METHODS: Sixty-one previously untreated small cell lung cancer patients with measurable lesion(s) received cisplatin(30 mg/m2 IV, day 1~3) and etoposide(100 mg/m2 IV, day 1~3). In patients with limited disease, after completion of 6 cycles of PVP chemotherapy, chest and prophylatic brain irradiation was performed in case of complete responder, chest irradiation only in partial responder. RESULTS: 1) Of 55 evaluable patients, 13(24%) had a complete response and 29(53%) had a partial response. 2) The median survival time was 55.8 weeks for all patients(N=55), 61.1 weeks for limited disease(N=31), 51.3 weeks for extensive disease(N=24). 3) The response duration was 29.1 weeks for responders(N=42). 4) There was no significant prognostic factors iufluencing response rates. 5) The toxicity was tolerable and there was no treatment-related deaths. CONCLUSION: The PVP combination chemotherapy as a first-line therapy was effective and well-tolerated in patients with small cell lung cancer.
