Hepatic resection margin predicts survival in colorectal cancer with hepatic metastasis.
10.14701/kjhbps.2012.16.2.55
- Author:
Jin Hyuk CHOI
1
;
Myung Hee YOON
Author Information
1. Department of Surgery, Kosin University College of Medicine, Busan, Korea. yoonmhj@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
Hepatic metastasis;
Prognostic factor
- MeSH:
Carcinoembryonic Antigen;
Colorectal Neoplasms;
Follow-Up Studies;
Humans;
Liver;
Neoplasm Metastasis;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2012;16(2):55-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUNDS/AIMS: Prognostic factors for colorectal cancer with hepatic metastasis are not well-established. We investigated the factors that predicted survival following surgical resection of hepatic metastases in patients with colorectal cancer. METHODS: Fifty-three patients underwent resection of hepatic metastases of colorectal cancer between January 2000 and December 2005, with follow-up periods that ranged from 3 to 119 months. In this retrospective study, the effects of sex, age, type of hepatic resection, T stage and N stage of the primary cancer, number and size of metastatic hepatic tumors, synchronicity or metachronicity of the liver metastases, surgical resection margins, and preoperative carcinoembryonic antigen (CEA) levels on 1-year and 3-year survival were analyzed using the Kaplan-Meier method and the log rank test. RESULTS: Median survival was 39.9 months and the 3-year survival rate was 62.2%. Twenty patients died during the follow-up period of 3 to 119 months (mean, 48.8+/-34.24). In univariate analysis, only the surgical margin of the hepatic metastasis resection correlated significantly with 3-year survival. Sex, age, T stage and N stage of the primary cancer, synchronicity or metachronicity of the metastases, number and size of hepatic metastases, type of hepatic resection and preoperative CEA levels did not predict long-term outcome. CONCLUSIONS: Hepatic resection provides a safe and effective treatment in patients with hepatic metastasis from colorectal cancer. In this study, only the surgical resection margin of the hepatic metastasis of colorectal cancer significantly predicted survival.
